Innovative Discovery Pilot Grant Funding

Congratulations to the 2019-2020 WHSC 10X Single Cell Sequencing Seed Grant Recipients

As part of its strategic plan implementation process under the theme of Innovative Discovery, the Emory Woodruff Health Sciences Center (WHSC) distributed a call for proposals for an inaugural round of 10X Single Cell Sequencing Seed Grant funding to support early-career WHSC investigators in the 2019-2020 academic year.

WHSC houses two 10X Chromium Controller instruments that enable the rapid generation of massively parallel encapsulated sequencing libraries for single cell sequencing. One instrument is located in the Emory Integrated Genomics Core on Emory's main campus and the second is located at the Yerkes Nonhuman Primate Genomics Core. This state-of-the-art technology provides WHSC investigators the ability to analyze the expression of thousands of genes in single cells, allowing them to identify new cell types and functions that have previously been unrecognized. The 10X platform decreases sequencing costs per cell and allows the analysis of thousands of cells in a single run to accurately analyze gene expression in cell populations from experimental samples.

The executive sponsors for the Innovative Discovery theme of the WHSC Strategic Plan are pleased to congratulate the following recipients of the inaugural round of 10X Single Cell Sequencing Seed Grants:

1. Abdul Arif, PhD
   Instructor, Department of Orthopaedics, School of Medicine (SOM)
   Crosstalk between bone-produced phospho-lipocalin-2 and brain cells during aging
2. Swati Bhasin, PhD
   Assistant Professor, Department of Pediatrics (Hematology/Oncology), SOM
   Dissecting the tumor and bone marrow heterogeneity in pediatric Acute Lymphoblastic Leukemia by three-dimensional single cell profiling
3. Pallavi Bhattaram, PhD
   Assistant Professor, Department of Orthopaedics, SOM
   Elucidating the roles of synovial lining fibroblasts in inflammatory joint diseases
4. Laura Hansen, PhD
   Assistant Professor, Department of Medicine (Cardiology), SOM
   Shifts in satellite cell populations and expression profiles may modulate their pro-vasculogenic function in response to ischemia or exercise
5. Sang-Ho Lee, PhD
   Instructor, Department of Medicine (Cardiology), SOM
   Time course analysis of single cell transcriptome during direct reprogramming of human fibroblasts into endothelial cells using ETV2
6. Rebecca Levit, MD
   Assistant Professor, Department of Medicine (Cardiology), SOM
   Evaluation of neutrophil phenotypic heterogeneity in health and disease
7. Xiulei Mo, PhD
   Instructor, Department of Pharmacology and Chemical Biology, SOM
   Deciphering Colon Cancer Heterogeneity at Single-Cell Resolution with a 3D Organoid Model
8. Karan Uppal, PhD
   Assistant Professor, Department of Medicine (Pulmonary, Allergy, Critical Care, and Sleep Medicine), SOM
   Systems medicine approaches for understanding the perturbations in the single cell lung transcriptome and lung metabolome as a result of low dose cadmium exposure
9. Jinhu Wang, PhD
   Assistant Professor, Department of Medicine (Cardiology), SOM
   Single-cell sequencing analysis of hapln1a positive cells in zebrafish heart

If you have any questions about WHSC Innovative Discovery pilot grant funding, please email Ashley Freeman at innovative.discovery@emory.edu.